GH Research plc


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Company Overview

GH Research is a clinical-stage biopharmaceutical company dedicated to transforming the treatment of psychiatric and neurological disorders.

The company's initial focus is on developing its novel and proprietary 5-Methoxy-N,N-Dimethyltryptamine, or 5-MeO-DMT, therapies for the treatment of patients with Treatment Resistant Depression, or TRD.

Its portfolio currently includes GH001, our proprietary inhalable 5-MeO-DMT product candidate, and GH002, its proprietary injectable 5-MeO-DMT product candidate.

GH Research has completed a Phase 1 healthy volunteer clinical trial, in which administration of GH001 via inhalation was observed to be well tolerated at the investigated single dose levels and in an individualized dosing regimen with intra-subject dose escalation.

GH001 is currently being investigated in the Phase 2 part of an ongoing Phase 1/2 clinical trial in patients with TRD. Based on observed clinical activity, the company believes that administration of a single dose of GH001 has the potential to induce ultra-rapid remissions as measured by the Montgomery-Åsberg Depression Rating Scale, or MADRS, in certain patients. The goal of the ongoing Phase 2 part of the trial is to assess whether an individualized dosing regimen with intra-subject dose escalation within a single day can further increase the MADRS remission rate as compared to a single GH001 dose.

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Management Team

Mr. Florian Schonharting M.Sc. (Econ)
Co-Founder & Non-Exec. Chairman

Mr. Theis Terwey M.D.
Co-Founder & CEO

Mr. Magnus Halle
Co-Founder & MD of Ireland

Ms. Julie Ryan A.C.A.
VP of Fin.

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